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The Revised International Staging System (RISS) is a way doctors organize multiple myeloma, a type of blood cancer, into three groups: Stage 1, Stage 2, and Stage 3. These stages show how much cancer is in the body, how serious it is, and how it might grow. This helps doctors choose the best treatment and understand what might happen next. The RISS looks at four things: • Serum beta-2 microglobulin: A protein in your blood. • Serum albumin: Another protein in your blood. • LDH: A protein that can show how active the cancer is. • Cytogenetics: Changes in the cancer’s genes. Understanding your Stage 1 Multiple Myeloma diagnosis will help you partner with your doctors to make the best treatment choice for you. Tap “Watch Now” for an easy-to-understand overview of Stage 1 Multiple Myeloma.
  • Stage 1 Multiple Myeloma

Overview

Multiple Myeloma Stage 1 is the earliest stage of the disease and is generally associated with a relatively favorable prognosis compared to later stages.

In Stage 1 of Multiple Myeloma, the following markers are typically observed:

  • Low levels of beta-2 microglobulin (less than 3.5 mg/L)
  • High levels of albumin (3.5 g/dL or more)
  • Normal LDH (lactate dehydrogenase)
  • No high-risk gene mutations present

What tests will I need and Why?

Blood and Imaging tests are done to understand your general health, confirm your diagnosis and determine your cancer stage.
A bone marrow biopsy is a procedure where a small sample of bone marrow is taken, usually from your hip bone, using a thin needle. This helps doctors examine your cells and identify the type of myeloma cells present. This information is important for finding the best treatment option for you.

If your treatment team has not already performed tests to determine your cancer’s features and stage, please ask your doctor when these tests will be performed.

Re-read this summary as needed and then tap, “Compare My Treatment Options Now“. Our unique Comparison Page will help you understand your FDA-approved treatment options including, who can help you pay for your treatment, where and how each is given and what side-effects you may experience.

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Cancerresearchuk.org